The wife is in a Mexican jail right now accused of smuggling marijuana.
CBS5 News spoke with the husband's brother-in-law Saturday.
Brandon Klippel said Gary and Yanira Maldonado were the only U.S. citizens on the bus – and if drugs were truly found on board, they were already there when the couple sat down.
"You hear all of these horror stories about Mexico and you think it's just something in the movies, right?" said Klippel. "You don't believe it's something that could happen to someone you know. But, when it happens to your brother and your sister - it's hard, it's tough to take."