The book, by Michael Lewis, was a New York Times best seller and introduced millions to BYU's online high school courses. Oher used BYU high school credits to become eligible for the college football scholarship that led to an NFL career.
Current high school athletes may not be able to duplicate Oher's path to college eligibility.
The NCAA said Tuesday it no longer will allow teenagers to use online high school course credit from BYU to beef up their grades in key classes. The NCAA also announced it won't recognize transcripts from the American School correspondence program in Illinois.
The move is part of new NCAA rules that require "regular access and interaction" between teachers and students in the 16 core courses required to establish initial eligibility for new college athletes.
The changes don't affect NCAA Division II schools, but a panel representing them will reconsider the measure in June.
BYU spokeswoman Carri Jenkins said the university learned of the change Friday.